Self-Substained Oscillations in the Jacob-Monod Mode of Gene Regulation
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چکیده
A plausible macroscopic model of genetic regulation by feedback repression, evolved from the original formulation of Goodwin, is considered. This model has the form of a second-order non-linear dynamic system, ~ = fl(x,y), # = f2(x,y), where x(t) ~ 0 describes the mRNA which codes for the protein y(t) ~ 0, the latter acting as a repressor. Published analytical, analog, and digital studies of this model do not report the existence of any periodic solutions. A stochastic analysis has produced some irregular undamped oscillations, but these appear to be due to the stochastic elements so introduced.
منابع مشابه
Repressors
Jacques Monod and Francois Jacob, our heroes, described a gene-regulatory world run exclusively by repressors. The activities of repressors, their abilities to bind DNA as we later learned, would be controlled — helped or hindered — by small molecules that bind these proteins. They showed [1] that networks of considerable complexity could be created with such a regulatory system. There was no n...
متن کاملFrancois Jacob (1920-2013)
François Jacob studied bacteria and bacteriophages at the Institut Pasteur in Paris, France, in the second half of the twentieth century. In 1965, Jacob won the Nobel Prize in Physiology or Medicine [3] with André M. Lwoff and Jacques L. Monod for their work on the genetic control of enzyme synthesis. Jacob studied how genes [4] control and regulate metabolic enzymes in the bacterium Escherichi...
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Between 1957 and 1959, Arthur Pardee, François Jacob, and Jacques Monod [5] conducted a set of experiments at the Pasteur Institute in Paris, France, that was later called the PaJaMa Experiments, a moniker derived from the researchers' last names. In these experiments, they described how genes [6] of a species of single-celled bacteria, called Escherichia coli [7] (E. coli ), controlled the pro...
متن کاملJacob and Monod: From Operons to EvoDevo
As Francois Jacob tells it, one afternoon in September 1958, just back from New York, he walked into Jacque Monod’s office at the Pasteur Institute in Paris; he believed he had something exciting to discuss. But he found an unimpressed Monod brusquely dismissive. Tired from his flight, Jacob quickly gave up and went home to bed. The next day he returned re-energized and found an altogether more...
متن کاملSemester 1 Lecture 10 : Motif Finding
First discovered in 1961 by Francois Jacob and Jacques Monod in Paris, regulation genes are a type of gene that provides the instructions for creating proteins which help control the expression of other structural genes. These genes play a key role in gene expression. From the DNA level to the protein level, we see that the protein coding genes, which occupy a small percentage of the genome, ar...
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تاریخ انتشار 1975